japanese encephalitis with pregnant women

Pregnancy outcome following infections by coxsackie, echo, measles, mumps, hepatitis, polio and encephalitis viruses
Reproductive Toxicology, Volume 21, Issue 4, May 2006, Pages 446-457
Asher Ornoy, Alexander Tenenbaumhttp://www.fp.ucalgary.ca/FMResidentSecure/Articles/Virus%20review.pdf

J Travel Med. 2007 Mar-Apr;14(2):117-28.

Congenital infections associated with international travel during pregnancy.
McGovern LM, Boyce TG, Fischer PR.
Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
http://onlinelibrary.wiley.com/doi/10.1111/j.1708-8305.2006.00093.x/pdf

Japanese Encephalitis Vaccines

Recommendations of the Advisory Committee on Immunization Practices (ACIP)

March 12, 2010 / 59(RR01);1-27

Inactivated Vero Cell Culture-Derived JE Vaccine (IXIARO [JE-VC])

Vaccination of Women During Pregnancy and Breastfeeding

FDA classifies JE-VC as a "Pregnancy Category B" medication (14). No controlled studies have assessed the safety, immunogenicity, or efficacy of JE-VC in pregnant women. Preclinical studies of JE-VC in pregnant rats did not show evidence of harm to the mother or fetus. No data exist on the safety or efficacy of JE-VC in breastfeeding women.

Inactivated Mouse Brain--Derived JE Vaccine (JE-VAX [JE-MB])

Vaccination of Women During Pregnancy and Breastfeeding

FDA classifies JE-MB as a "Pregnancy Category C" medication (146). No specific information is available on the safety of JE-MB in pregnant women, and animal reproductive studies have not been conducted with JE-MB. In addition, no data exist on the safety or efficacy of JE-MB in breastfeeding women.

http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5901a1.htm
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Travelers' Health - Yellow Book

Chapter 2The Pre-Travel Consultation

 Japanese Encephalitis (JE)

No specific information is available on the safety of JE vaccine in pregnancy. Therefore, the vaccine should not be routinely administered during pregnancy. Pregnant women who must travel to an area where risk for JE is high should be vaccinated when the theoretical risk for immunization is outweighed by the risk for infection.

 http://wwwnc.cdc.gov/travel/yellowbook/2010/chapter-2/japanese-encephalitis.aspx#816
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JAPANESE ENCEPHALITISVACCINE
JE-VAX®
Pregnant women should generally not get JE vaccine. But if you are pregnant, check with your doctor. It could be recommended under certain circumstances.
http://www.immunize.org/vis/je_vax.pdf
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 Guidelines for Vaccinating Pregnant Women

Vaccine		Should be considered if otherwise indicated	Contraindicated during pregnancy	Special/Conditional Recommendation (see text)
Routine	Hepatitis A			See Hepatitis A text
	Hepatitis B	X
	Human Papillomavirus (HPV)			See HPV text
	Influenza (Inact.)	Recommended
	Influenza (LAIV) *		X
	Measles*		X
	Meningococcal (MCV4)			See Meningococcal text
	Mumps*		X
	Pneumococcal			See Pneumococcal text
	Polio (IPV)			See Polio text
	Rubella*		X
	Tetanus - Diphtheria	X
	Tetanus - Diphtheria - Pertussis (Tdap)			See Tdap text
	Varicella		X
Travel & Other	Anthrax			See Anthrax text
	BCG*		X
	Japanese Encephalitis			See Japanese Encephalitis text
	Meningococcal (MPSV4)	X
	Rabies	X
	Typhoid (Parenteral & Oral*)			See Typhoid text
	Vaccinia*		X	See Vaccinia text
	Yellow Fever*			See Yellow Fever text
	Zoster*		X

Japanese Encephalitis (JE)

• No specific information is available on the safety of JE vaccine in pregnancy .Vaccination poses an unknown but theoretical risk to the developing fetus, and the vaccine should not be routinely administered during pregnancy.

 http://www.cdc.gov/vaccines/pubs/preg-guide.htm#16

 

 

Recommendations and Reports